Placebo analgesia

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PLACEBO ANALGESIA 1 Placebo Analgesia

SUMMARY The expectation of pain relief can exert a powerful analgesic effect, even when pain is severe. Depending on the nature of experiences and instructions provided, a placebo analgesic effect can be elicited acutely in a very large percentage of individuals, in both experimental and clinical contexts. Placebo analgesia has been linked with activity in the prefrontal cortex, endogenous opio...

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Central inhibition and placebo analgesia

Most neuroscientists measure neuronal activity in the brain to predict or explore the contribution of neurons to physiological/pathological functions of the brain. For example, if an increase in neuronal activity is detected in one brain region by peripheral noxious stimuli, we call this area the pain region or pain matrix. In the case of activity detected during conscious processes, such as pl...

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Placebo‐like analgesia via response imagery

BACKGROUND Placebo effects on pain are reliably observed in the literature. A core mechanism of these effects is response expectancies. Response expectancies can be formed by instructions, prior experiences and observation of others. Whether mental imagery of a response can also induce placebo-like expectancy effects on pain has not yet been studied systematically. METHODS In Study 1, 80 heal...

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Placebo analgesia: psychological and neurobiological mechanisms.

National Center for Complementary and Alternative Medicine (NCCAM), National Institute of Mental Health (NIMH) and Clinical Center, Department of Bioethics, National Institutes of Health (NIH), Bethesda, MD, USA Outpatient Clinic of Behavior Therapy, Department of Psychology, University of Hamburg, Hamburg, Germany Department of Cognitive and Clinical Neuroscience, Central Institute of Mental H...

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Placebo Analgesia: A Predictive Coding Perspective

This Perspective reviews recent findings in placebo hypoalgesia and provides a conceptual account of how expectations and experience can lead to placebo hypoalgesia. In particular, we put forward the idea that the ascending and the descending pain system resembles a recurrent system that allows for the implementation of predictive coding-meaning that the brain is not passively waiting for nocic...

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ژورنال

عنوان ژورنال: Journal of the Royal Society of Medicine

سال: 2000

ISSN: 0141-0768,1758-1095

DOI: 10.1177/014107680009300819